%% Solve Fokker Planck equation for given parameter set % Define parameters for tanh, according to Weber, Zwicker, Julicher, Lee. b = @(chi, nu) nu^(1/3)*sqrt(chi/(chi-2)); e = @(chi) sqrt(3/8*(chi-2)); t = [0, 0.01, 0.05, 50]; %% Try out different precisions % prec = [0.5, 0.5, 1, 2, 3.5, 5]; fac = [1, 5, 10];%, 10, 100]; for i = 1:length(fac) tic b = 2e-4; u0 = 0.5; P=1; D_i = 2; D_o = 20; a = -1; [b, u0, e, e_g, u_g] = calc_tanh_params(fac(i)*P, D_i, fac(i)*D_o, a, b, u0); T_prec(i) = Ternary_model(2, 'FRAP', {-1, b, u0, ... e, e_g, u_g, 300, 7, 0, 'Constituent'},... t, 2000); % T_prec(i) = Ternary_model(2, 'FRAP', {-1, b(7.7/3, 10^-5), u0, ... % e(7.7/3), e_g, u_g, 300, 7, 0, 'Constituent'},... % t, 0.2); T_prec(i).solve_tern_frap() toc end %% Test partitioning == 1 compared to natural no mobility case. % Tg1: g0 = 1 everywhere. Tpt1 = Ternary_model(0, 'FRAP', {-1, b(7/3, 10^-18), 0.5, e(7/3),... 0, 1, 300, 7, 0, 'Constituent'},... t, 1); Tpt1.solve_tern_frap(); %% % Rescale mobility, such that phi_tot=1 everywhere achieves same flux Gi = (1-Tpt1.phi_t(1))/(1-Tpt1.phi_t(1)); Go = Tpt1.phi_t(1)/Tpt1.phi_t(end)*(1-Tpt1.phi_t(end)); %% Tga1 = Ternary_model(0, 'FRAP', {-1, b(7/3, 10^-18), Tpt1.phi_t(1), 0,... (Go-Gi), Gi, 300, 7, 0, 'Constituent'},... t, 1); Tga1.solve_tern_frap(); %% Tpt1.plot_sim('plot', 1, 'g') %% Tga1.plot_sim('plot', 1, 'k') %% figure(3); hold on; % fact = [0.9965, 0.94, 1.01, 1.98];fact(i)* c = {'g', 'm', 'k', 'r'}; for i = 1:3%length(T_prec) % T_prec(i).plot_sim('plot', 1, c{i}) % Is this the right normalization? %/T_prec(i).phi_t(1) plot(T_prec(i).x, T_prec(i).sol'/T_prec(i).phi_t(1), c{i}); axis([0, 20, -inf, 1]); end axis([0, 2, 0, 1]) %% Same precisions, different starting positions x0 = [-0.05, -0.03, -0.01, 0.01, 0.03, 0.05]; parfor i = 1:length(x0) T_diff_x0(i) = Ternary_model(0, 'Gauss', [-6, b(7.7/3, 10^-6), 0.5, ... e(7.7/3), 0, 1, 300, 6+x0(i)], t, 0.5); T_diff_x0(i).solve_tern_frap() end %% for i = 1:length(T) csvwrite(['x_X73_', num2str(x0(i)), '.csv'], T_diff_x0(i).x+T(i).a); csvwrite(['sol_X73_', num2str(x0(i)), '.csv'], T_diff_x0(i).sol(:, :)); end %% Frank's/Stefano via Laplace transform vs Fokker Planck t = linspace(0, 10, 1000); tic T_mov = Ternary_model(0, 'Gauss', {-6, b(7/3, 10^-15), 0.5, e(7/3),... 19, 1, 300, 7, 0, 'Constituent'}, t, 0.2); T_mov.solve_tern_frap() toc %% p_out = @(D_p, D_m, ga, x0, x, t) 1./(2*sqrt(D_p*pi*t))*... (exp(-(x+x0).^2./(4*D_p*t))*(ga*sqrt(D_p)-sqrt(D_m))./... (ga*sqrt(D_p)+sqrt(D_m))+exp(-(x-x0).^2./(4*D_p*t))); p_in = @(D_p, D_m, ga, x0, x, t) 1./(sqrt(pi*t)*(sqrt(D_m)+... ga*sqrt(D_p)))*exp(-(x-x0*sqrt(D_m/D_p)).^2/(4*D_m*t)); x_left = linspace(-4, 0, 1000); x_right = linspace(0, 4, 1000); %% Plot with full ternary model T_temp = T_mov; D_m = 1*(1-T_temp.u0-T_temp.e); % to make equal to ternary FRAP D_p = 20*(1-T_temp.u0+T_temp.e); ga = (T_temp.u0-T_temp.e)/(T_temp.u0+T_temp.e); for i = 1:100%length(T_mov.t) cla; figure(1); hold on; xlim([-2, 2]); ylim([0, 1]); plot(T_temp.x+T_temp.a, T_temp.sol(i, :), 'r.');%, 'LineWidth', 2); plot(x_left, p_in(D_p, D_m, ga, T_temp.x0+T_temp.a, x_left,... t(i)+0.01/1000), 'k-.', 'LineWidth', 2); plot(x_right, p_out(D_p, D_m, ga, T_mov.x0+T_temp.a, x_right,... t(i)+0.01/1000), 'k-.', 'LineWidth', 2); plot(x_left, p_in(10*D_p, D_m, ga/1, T_temp.x0+T_temp.a, x_left,... t(i)+0.01/1000), 'b-.', 'LineWidth', 2); make_graph_pretty(['x [' char(956) 'm]'], 'c [a.u.]', '',... [T_temp.a, 10, 0, inf]) % print([num2str(i),'.png'],'-dpng') shg; pause(); end %% Moving boundary t = linspace(0, 10, 9000); tic T_mov = Ternary_model(0, 'phi_tot', {-10, b(7/3, 10^-6), 0.5, e(7/3),... 0, 1, 10, 7, 0.5, 'Client'}, t, 0); T_mov.solve_tern_frap(); toc norm_fac = 1/sum(diff(T_mov.x).*... (T_mov.sol(1, 1:end-1)+T_mov.sol(1, 2:end))/2); s = '~/Nextcloud/Langevin_vs_MeanField/Data_Figs_FokkPla/'; csvwrite([s, 'MovingBound.csv'], [T_mov.x', norm_fac*T_mov.sol(1, :)',... norm_fac*T_mov.sol(end, :)']) %% Flux and entropy change for moving boundary chi_phi = -4.530864768482371; s_dot = zeros(1, length(T_mov.t)); for i = 1:length(T_mov.t) x_interp = (T_mov.x(1:end-1)+T_mov.x(2:end))/2; u = norm_fac*T_mov.sol(i, :); u_interp = (u(1:end-1)+u(2:end))/2; g0 = 0.5; gra_a = Ternary_model.gradient_analytical(x_interp, T_mov.a, T_mov.b,... T_mov.e, T_mov.v*T_mov.t(i)); dudx = diff(u)./diff(T_mov.x); f = -g0*(dudx+chi_phi.*u_interp.*gra_a); s_dot(i) = sum(diff(T_mov.x).*f.^2./(g0.*u_interp)); % figure(1); hold on; % plot(0:10, zeros(1, 11), 'LineWidth', 2); % plot(x_interp, f, 'LineWidth', 2) % set(gca,'fontsize', 18) % make_graph_pretty(['x [' char(956) 'm]'], 'flux', '',... % [0, T_mov.system_size, min(f(:)), max(f)]) % pause() end csvwrite([s, 'Mov_Bou_Flux.csv'], [x_interp; f]) csvwrite([s, 'Mov_Bou_Entr.csv'], [T_mov.t; s_dot]) %% FRAP jump length t = linspace(0, 5, 300); T_mov = Ternary_model(0, 'FRAP', {-5, b(7/3, 10^-6), 0.5, e(7/3),... 0, 1, 10, 7, 0, 'Constituent'}, t, 0.2); T_mov.solve_tern_frap(); norm_fac = 1/sum(diff(T_mov.x)... .*(T_mov.sol(1, 1:end-1)+T_mov.sol(1, 2:end))/2); s = '~/Nextcloud/Langevin_vs_MeanField/Data_Figs_FokkPla/'; csvwrite([s, 'FRAP.csv'], [T_mov.x', norm_fac*T_mov.sol(1, :)',... norm_fac*T_mov.sol(end, :)']) %% Flux and entropy change for FRAP s_dot = zeros(1, length(T_mov.t)); for i = 1:length(T_mov.t) x_interp = (T_mov.x(1:end-1)+T_mov.x(2:end))/2; u = norm_fac*T_mov.sol(i, :); u_interp = (u(1:end-1)+u(2:end))/2; pt = Ternary_model.phi_tot(x_interp, T_mov.a, T_mov.b, T_mov.e,... T_mov.u0, T_mov.v*T_mov.t(i)); gra_a = Ternary_model.gradient_analytical(x_interp, T_mov.a, T_mov.b,... T_mov.e, T_mov.v*T_mov.t(i)); g0 = Ternary_model.gamma0(x_interp, T_mov.a+T_mov.v*T_mov.t(i), T_mov.b,... T_mov.e_g0, T_mov.u_g0, T_mov.v*T_mov.t(i)); dudx = diff(u)./diff(T_mov.x); f = -g0.*(1-pt)./pt.*(pt.*dudx-u_interp.*gra_a); s_dot(i) = sum(diff(T_mov.x).*f.^2./(g0.*(1-pt).*u_interp)); % figure(1); hold on; cla; % plot(x_interp, f) % pause() end csvwrite([s, 'FRAP_Flux.csv'], [x_interp; f]) csvwrite([s, 'FRAP_entropy.csv'], [T_mov.t; s_dot]); %% Check integral of solution, should be mass conserving and sum to 1. % integrate to 50, to avoid right boundary [~, ind] = min(abs(T_prec(4).x-50)); bins = (T_prec(4).sol(:, 1:ind-1)+T_prec(4).sol(:, 2:ind))/2; bin_size = diff(T_prec(4).x(1:ind)); sum(bins(4, :).*bin_size) %% figure; hold on; T_prec(1).plot_sim('plot', 10, 'magenta') T_prec(2).plot_sim('plot', 10, 'red'); T_prec(3).plot_sim('plot', 10, 'green'); T_prec(4).plot_sim('plot', 10, 'k'); T_prec(5).plot_sim('plot', 10, 'blue'); %% Check whether partitioning factor is kept throughout simulation. % This should work for steep boundaries. for i = 1:4 pks_min = findpeaks(-T_prec(5).sol(i, :)); pks_max = findpeaks(T_prec(5).sol(i, :)); pks_max(1)/pks_min(1) end %% Solve integrals for jump length distribution @ steady state. % Set parameters params = {-5, b(7.7/3, 10^-6), 0.5, e(7.7/3), 0, 1, 10, 7, 0, 'Constituent'}; t = [0, 0.05, 0.1]; x0 = 5.0:0.002:7.01; %% Run simulations with 'delta' IC across outside T = {}; parfor i = 1:length(x0) tic T{i} = Ternary_model(0, 'Gauss', params, t, 0.2); T{i}.x0 = x0(i); T{i}.solve_tern_frap(); toc end % save prob_laplace_X_7_7_short_2 %% Calculate probabilities for each jump length in ls. ls = 0.0005:0.005:2; p = nan(1, length(ls)); tic parfor i = 1:length(ls) p(i) = int_prob(ls(i), T, x0, 0); end toc %% Test integrals int_prob(0.3, T, x0, 0.1) int_prob_simple(0.01, T, x0) %% Normalization factor N = normalization(T, x0, 0); %% Do we need to look at the left side as well? figure; hold on; plot(ls, p/N); %% Write to file csvwrite('jump_length_7_7_lb01.csv', ls) csvwrite('prob_7_7_lb01.csv', p/N); %% Distribution for x0 can be taken from phi_tot (steady state) function p = int_prob(l, T, x0, lb, T_mov, ind_t, ind_delta) delta_x0 = diff(x0); p = 0; for i = 1:length(delta_x0) x = (x0(i)+x0(i+1))/2; if x-5>lb if x-l > 5-lb; break; end if nargin==4 p_i = @(j) interp1(T{j}.x, T{j}.sol(3, :), x-l); p2 = (p_i(i)+p_i(i+1))/2; p = p + delta_x0(i)*... T{1}.phi_tot(x, T{1}.a, T{1}.b, T{1}.e, T{1}.u0, 0)*p2; elseif nargin==7 p_i = @(j) interp1(T{j}.x, T{j}.sol(ind_t+ind_delta, :), x-l); p2 = (p_i(i)+p_i(i+1))/2; p_sol = @(j) interp1(T_mov.x, T_mov.sol(ind_t, :), x); p_sol2 = (p_sol(i)+p_sol(i+1))/2; p = p + delta_x0(i)*p_sol2*p2; end end end end function p = int_prob_simple(l, T, x0) p = 0; p_i = @(j, x0) interp1(T{j}.x, T{j}.sol(3, :), x0-l); for i = 1:length(x0) if x0(i)-l > 5; break; end % Is this right? % Calculate left bin boundary if i == 1 left_bound = -T{1}.a; else left_bound = (x0(i)-x0(i-1))/2; end % Calculate right bin boundary if i == length(x0) right_bound = T{1}.system_size; else right_bound = (x0(i+1)+x0(i))/2; end bin_width = right_bound-left_bound; p = p + bin_width*... T{1}.phi_tot(x0(i), T{1}.a, T{1}.b, T{1}.e, T{1}.u0, 0)*... p_i(i, x0(i)); end end function p = normalization(T, x0, lb) delta_x0 = diff(x0); logi = T{1}.x<5-lb; delta_x = diff(T{1}.x(logi)); p_i = zeros(1, length(delta_x0)); for i = 1:length(delta_x0) sol = T{i}.sol(3, logi); sol = (sol(1:end-1)+sol(2:end))/2; x = (x0(i)+x0(i+1))/2; if x > 5+lb p_x0i = T{1}.phi_tot(x, T{1}.a, T{1}.b, T{1}.e, T{1}.u0, 0); p_i(i) = delta_x0(i)*sum(sol.*delta_x)*p_x0i; end end p = sum(p_i); end