AboutPage.vue

<template>
  <div
    id="page-content-wrapper"
    class="main"
  >
    <h2>DD-Code</h2>
    <p>
      DD-CODE is a comprehensive, manually curated database for biomolecular condensates and their constituents as well as an encyclopedia for the scientific terms used to describe and characterize them.  Biomolecular condensates are cellular structures that are formed by phase separation, which is a thermodynamically passive process by which a homogeneous liquid solution (or phase) of macromolecular components separates (or demixes) into two distinct phases, one phase which is enriched for the macromolecules (<b>dense</b>) and another phase that is depleted of the same macromolecules (<b>dilute</b>).  This allows for selective enrichment (or depletion) of certain proteins, thereby facilitating compartmentalization.  In cells, phase separation is driven by <b>driver</b> proteins/nucleic acids, which in turn recruit <b>client</b> molecules into the condensate.  It is important to note that a particular protein/nucleic acid may be a driver in one condensate but the client in another.  Moreover, the formation of condensates might be regulated by <b>regulator</b> proteins through specific biochemical activities,  such as kinases, but they do not necessarily need to be a part of the condensate.  Phase separation is now thought to underlie many biological processes, including heterochromatin formation, nucleocytoplasmic transport, and the formation of membraneless compartments such as nucleoli.  Membraneless compartments exhibit various material properties, such as liquid-like compartments (e.g. P-granules), amorphous gels (e.g. centrosomes), dynamic solids (e.g. microtubules).  The “hardening” or aging of liquid-like compartments is also linked to various human diseases, such as neurological disease.
    </p>
    <p>
      We hope that DD-CODE becomes a valuable resource for the phase separation and condensate community.  The DD-CODE project aims to 1) collect information on all biomolecular condensates and their constituents; 2) create an encyclopedia and ontology of the scientific terms and definitions used by the community; and 3) standardise the terminology of the field.  All data are manually curated and experimental details and references are provided; this forms the basis of our scoring system for experimental evidence for condensate formation.
    </p>
    <p>
      Condensate biology is an exciting, new, dynamic and rapidly growing field illustrated by the steep growth in the number of publications in PubMed.  Here, we engage the community to codify and validate scientific information via crowd-scourcing.  Become an annotator!
    </p>

    <ul class="a">
      <li>Database: <a href="/">DD-CODE</a></li>
      <li><a href="/encyclopedia">Definitions</a></li>
      <li><a href="/">Crowdsourcing</a></li>
      <li><a href="/about">Evidence stars</a></li>
    </ul>
  </div>
</template>

<script>
const _ = require('lodash')

export default {
  name: 'LandingPage',
  components: {
  },
  props: {
    msg: String
  },
  data() {
    return {
    }
  },
  computed: {
  },
  methods: {
  }
}
</script>

<!-- Add "scoped" attribute to limit CSS to this component only -->
<style>
@import url('~@/assets/bootstrap.css');

.main {
  margin: 1.5rem;
}

h3 {
  margin: 40px 0 0;
}

a {
  color: #42b983;
}

ul.a {
  list-style-type: disc;
  list-style-position: inside;
}

input[type="radio"] {
  margin: 2px;
}

.radio-label {
  margin-left: 0px;
  margin-right: 5px;
}
</style>